Abstract Title:

Metabolic endotoxemia and cardiovascular disease: a systematic review about potential roles of prebiotics and probiotics.

Abstract Source:

Clin Exp Pharmacol Physiol. 2020 Jan 2. Epub 2020 Jan 2. PMID: 31894861

Abstract Author(s):

Jalal Moludi, Vahid Maleki, Hamed Jafari-Vayghyan, Elnaz Vaghef-Mehrabany, Mohammad Alizadeh

Article Affiliation:

Jalal Moludi


Translocation of microbiome-derived lipopolysaccharide (LPS) to the bloodstream (Metabolic endotoxemia) is associated with significantly increased risk of cardiovascular diseases (CVD); however, the direction of this association is not fully understood. It has been revealed by some studies that alterations in the intestinal microbiota (dysbiosis) lead to increased intestinal permeability and translocation of LPS to the blood circulation. LPS may trigger toll-like receptor 4- (TLR-4) mediated inflammatory responses; this could lead to chronic low-grade proinflammatory condition named Metabolic endotoxemia (ME), which is typically observed in CVD patients. ME is promoted by increased intestinal permeability. Moreover, dysbiosis leads to production of Trimethylamine-N-oxide (TMAO), a gut bacterial metabolite suggested as a new risk factor in CVD development. Probiotics, extensively reviewed for decades, are live microorganisms which when taken in adequate amounts, have beneficial effects on the host metabolism. Prebiotics are a type of dietary fiber that act as nourishment for the good bacteria in the gut, and decrease the population of pathogen bacteria that produce greater amount of endotoxins. Although an association has been postulated between ME and CVD, the results of studies investigating the role of antibiotic therapy in preventing the disease have been inconsistent. In this review, we discuss how prebiotics and probiotics modulate gut microbiota and consequently might help with prevention and/or treatment of CVD associated with ME.

Study Type : Review

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.