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Abstract Title:

Metabolic profiling study of shikonin's cytotoxic activity in the Huh7 human hepatoma cell line.

Abstract Source:

Mol Biosyst. 2017 May 2 ;13(5):841-851. PMID: 28265634

Abstract Author(s):

E D Spyrelli, A V Kyriazou, C Virgiliou, A Nakas, O Deda, V P Papageorgiou, A N Assimopoulou, H G Gika

Article Affiliation:

E D Spyrelli

Abstract:

Shikonin and its enantiomer alkannin, which are natural products, have been extensively studied in vitro and in vivo for, among others, their antitumor activity. The investigation of the molecular pathways involved in their action is of interest, since they are not yet clearly defined. Metabolic profiling in cells can provide a picture of a cell's phenotype upon intervention, assisting in the elucidation of the mechanism of action. In this study, the cytotoxic effect of shikonin on a human hepatocarcinoma cell line was studied. Huh7 cells were treated with shikonin at 5μM, and it was found that shikonin markedly inhibited cell growth. Metabolic profiling indicated alterations in the metabolic content of the cells and the culture media upon treatment, detecting the metabolic response of the cells. This study demonstrates the potential of metabolomics to improve knowledge on the mechanisms involved in shikonin's antitumor action.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytotoxicity

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