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Article Publish Status: FREE
Abstract Title:

MethanolicL. Extract Ameliorates Cisplatin-Induced Hepatic Injury in Male Rats.

Abstract Source:

Nutrients. 2022 Feb 28 ;14(5). Epub 2022 Feb 28. PMID: 35268000

Abstract Author(s):

Heba Nageh Gad El-Hak, Hany Salah Mahmoud, Eman A Ahmed, Heba M Elnegris, Tahany Saleh Aldayel, Heba M A Abdelrazek, Mohamed T A Soliman, Menna Allah I El-Menyawy

Article Affiliation:

Heba Nageh Gad El-Hak

Abstract:

This study investigated the ameliorative potential of methanolic date flesh extract (MDFE) against cisplatin-induced hepatic injury. Twenty male rats (weighing 180-200 g) were allocated into four groups: control; date flesh (DF) group (oral 600 mg/kg MDFE for 21 days); Cis group (7.5 mg/kg i.p. at day 16); and date flesh/cisplatin (DF/Cis) group (oral 600 mg/kg MDFE for 21 days and 7.5 mg/kg i.p. at day 16). Hepatic biochemical parameters in sera, and inflammatory and oxidant/antioxidant hepatic biomarkers were estimated. Hepatic histological changes and the immunohistochemistry of cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-κB), and alpha smooth muscle actin (α-SMA) were assessed. Pretreatment with MDFE decreased Cis-triggered liver biochemical parameters, oxidative stress, inflammatory biomarkers, and histological damage. Moreover, MDFE treatment reduced Cis-induced hepatic NF-κB, COX-2, and α-SMA protein expression. MDFE exerted a hepatoprotective effect when used concomitantly with Cis. Its effect was mediated via its antioxidant and anti-inflammatory ingredients.

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