Article Publish Status: FREE
Abstract Title:

Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis.

Abstract Source:

World J Hepatol. 2014 Feb 27 ;6(2):98-106. PMID: 24575169

Abstract Author(s):

Joo-Hyun Kim, Hye-Jun Shin, Hye-Lin Ha, Young-Ho Park, Tae-Ho Kwon, Mi-Ra Jung, Hyung-Bae Moon, Eun-Sang Cho, Hwa-Young Son, Dae-Yeul Yu

Article Affiliation:

Joo-Hyun Kim


AIM: To investigate the effect of methylsulfonylmethane (MSM), recently reported to have anti-cancer effects, in liver cancer cells and transgenic mice.

METHODS: Three liver cancer cell lines, HepG2, Huh7-Mock and Huh7-H-ras (G12V), were used. Cell growth was measured by Cell Counting Kit-8 and soft agar assay. Western blot analysis was used to detect caspases, poly (ADP-ribose) polymerase (PARP), and B-cell lymphoma 2 (Bcl-2) expressions. For in vivo study, we administered MSM to H-ras (12V) transgenic mice for 3 mo.

RESULTS: MSM decreased the growth of HepG2, Huh7-Mock and Huh7-H-ras (G12V) cells in a dose-dependent manner. That was correlated with significantly increased apoptosis and reduced cell numbers in MSM treated cells. Cleaved caspase-8, cleaved caspase-3 and cleaved PARP were remarkably increased in the liver cancer cells treated with 500 mmol/L of MSM; however, Bcl-2 was slightly decreased in 500 mmol/L. Liver tumor development was greatly inhibited in the H-ras (12V) transgenic mice treated with MSM, compared to control, by showing reduced tumor size and number. Cleaved PARP was significantly increased in non-tumor treated with MSM compared to control.

CONCLUSION: Liver injury was also significantly attenuated in the mice treated with MSM. Taken together, all the results suggest that MSM has anti-cancer effects through inducing apoptosis in liver cancer.

Study Type : Animal Study

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