Abstract Title:

Microbial regulation of microRNA expression in the brain-gut axis.

Abstract Source:

Curr Opin Pharmacol. 2019 Oct 4 ;48:120-126. Epub 2019 Oct 4. PMID: 31590111

Abstract Author(s):

Gerard M Moloney, Timothy G Dinan, Gerard Clarke, John F Cryan

Article Affiliation:

Gerard M Moloney


The gut microbiome facilitates a consistent transfer of information between the gut and the brain and microRNAs may now represent a key signalling molecule that facilitates this relationship. This review will firstly examine how these small non-coding RNAs influence the gut microbiome, and secondly how the microbiome, when disturbed, may influence miRNA expression in the brain. In addition, we will examine the consequence that microbiome-related changes in miRNA expression have on neurodevelopment, behaviour and cognition. We will also discuss novel data that suggests miRNAs contained in our diet may influence our immune system in a positive manner, offering a further potential pathway for treatment of disorders of the gut-brain axis that are influenced by the microbiome.

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