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Article Publish Status: FREE
Abstract Title:

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.

Abstract Source:

Cell. 2020 Nov 23. Epub 2020 Nov 23. PMID: 33296701

Abstract Author(s):

Lauren B Rodda, Jason Netland, Laila Shehata, Kurt B Pruner, Peter A Morawski, Christopher D Thouvenel, Kennidy K Takehara, Julie Eggenberger, Emily A Hemann, Hayley R Waterman, Mitchell L Fahning, Yu Chen, Malika Hale, Jennifer Rathe, Caleb Stokes, Samuel Wrenn, Brooke Fiala, Lauren Carter, Jessica A Hamerman, Neil P King, Michael Gale, Daniel J Campbell, David J Rawlings, Marion Pepper

Article Affiliation:

Lauren B Rodda

Abstract:

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.

Study Type : Human Study
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Additional Keywords : Immune Memory

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