Article Publish Status: FREE
Abstract Title:

Miller Fisher syndrome following Pfizer COVID-19 vaccine.

Abstract Source:

Neurol Sci. 2022 Mar ;43(3):1495-1497. Epub 2021 Nov 24. PMID: 34817727

Abstract Author(s):

Ana Abičić, Ivan Adamec, Mario Habek

Article Affiliation:

Ana Abičić


INTRODUCTION: Miller Fisher syndrome (MFS) is a rare variant of Guillain-Barre syndrome characterized by ataxia, areflexia, and ophthalmoplegia. We present a case of MFS following Pfizer COVID-19 vaccine.

CASE PRESENTATION: A previously healthy 24-year-old female presented with binocular horizontal diplopia 18 days after receiving the first dose of Pfizer COVID-19 vaccine (Comirnaty®). Anti-ganglioside testing revealed positive anti-GQ1b antibodies. Intravenous immunoglobulins were administered, in a dose of 2 g per kg of body weight over 5 days. On a follow-up exam 3 weeks after the treatment, clinical improvement was noted with normal bulbomotor examination.

CONCLUSION: Patients with acute ophthalmoplegia occurring after COVID-19 vaccination should be screened for the presence of anti-GQ1b antibody. If the antibody is present, intravenous immunoglobulin should be administered as it may hasten clinical improvement.

Study Type : Human: Case Report

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