Abstract Title:

Mind-body interrelationship in DNA methylation.

Abstract Source:

Chem Immunol Allergy. 2012 ;98:85-99. Epub 2012 Jun 26. PMID: 22767059

Abstract Author(s):

Moshe Szyf

Article Affiliation:

Department of Pharmacology and Therapeutics, Sackler Program in Epigenetics and Psychobiology, McGill University, Montreal, Que., Canada.


DNA methylation is an enzymatic modification of the DNA molecule that confers unique differential identities upon similar DNA sequences. DNA methylation plays a critical role in cellular differentiation by conferring cell-type identity upon differentiated tissues in multicellular organisms by an innate developmentally programmed process. Recent data points to the possibility that DNA methylation plays a role in responding to external cues and conferring environment-context identity to DNA. DNA methylation is implicated in the response to early life social environment and might be playing an important role in setting up stable behavioral phenotypes in response to early-life social environment. The critical question is whether these responses are limited to the brain or involve the immune system as well. Addressing this question has important implications on understanding the mechanisms involved in DNA methylation mediated responses to the environment and how they impact the phenotype as well as on the possibility of studying the associations between DNA methylation and behavior and behavioral pathologies in living humans. A model is presented suggesting that DNA methylation acts as a mechanism of genome adaptation to the environment that is genomewide and systemwide. New data suggesting associations between DNA methylation patterns in white blood cells and the social environment will be discussed.

Study Type : Review
Additional Links

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.