Abstract Title:

Liver injury due to 3-amino-1-methyl-5h-pyrido [4,3-b] indole (Trp-P-2) and its prevention by miso.

Abstract Source:

Biosci Biotechnol Biochem. 2008 Aug;72(8):2236-8. Epub 2008 Aug 7. PMID: 18685190

Abstract Author(s):

Hiroyuki Suzuki, Hideyuki Sone, Ken Kawamura, Kazuo Ishihara


Trp-P-2(3-amino-1-methyl-5H-pyrido [4,3-b] indole) ingestion for 42 d by C3H/HeJJcl mice caused elevation of serum alanine transaminase (ALT) activity and several signs of liver injury. These alterations were not observed in mice fed the diet supplemented with 10% miso. This suggests a preventive effect of miso as to Trp-P-2 induced liver injury.

Study Type : Animal Study

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