Abstract Title:

In vitro response of stimulated B-CLL lymphocytes of patients treated with Viscum album L. extracts.

Abstract Source:

Anticancer Res. 2007 Nov-Dec;27(6B):4195-200. PMID: 18225591

Abstract Author(s):

Arndt Büssing, Heidi Kochskämper, Sabine Rieger, Jörg Michael Schierholz, Dietrich Schlodder, Michael Schietzel

Article Affiliation:

Chair of Medical Theory and Complementary Medicine, University Witten/Herdecke, Gerhard-Kienle-Weg 4, D-58313 Herdecke, Germany. [email protected]


BACKGROUND: Extracts from Viscum album (VA-E) have been shown to induce apoptosis and immunoactivation. To exclude possible B-CLL propagating effects, the in vitro reactions of cultured peripheral blood B-CLL cells were analysed. PATIENTS AND METHODS: Intracellular expression of apoptosis-associated mitochondrial Apo2.7 and proliferation-associated Ki-67 molecules in B-CLL cells from patients treated with VA-E for 12 months were measured after incubation with various stimuli. RESULTS: Within the observation period, the susceptibility of the B-CLL cells towards the apoptosis-inducing potential of the VA-E significantly decreased. This effect could be due to the presence of physiologically-induced anti-mistletoe lectin antibodies which may block the effects of cytotoxic mistletoe lectins. No significant induction of Ki-67 was observed, but an increase of non-specific binding, even in untreated medium controls, did occur within the last months. CONCLUSION: In this in vitro setting of the observational study, no stimulation of leukemic cells from the patients treated with VA-E was profound.

Study Type : Human Study

Print Options

Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.