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Article Publish Status: FREE
Abstract Title:

Mitoprotective Effects of(L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease.

Abstract Source:

Front Pharmacol. 2021 ;12:687935. Epub 2021 Jun 29. PMID: 34267660

Abstract Author(s):

Jia Hui Wong, Anna M Barron, Jafri Malin Abdullah

Article Affiliation:

Jia Hui Wong

Abstract:

Natural products remain a crucial source of drug discovery for accessible and affordable solutions for healthy aging.(L.) Urb. (CA) is an important medicinal plant with a wide range of ethnomedicinal uses. Pastandstudies have shown that the plant extract and its key components, such as asiatic acid, asiaticoside, madecassic acid and madecassoside, exhibit a range of anti-inflammatory, neuroprotective, and cognitive benefits mechanistically linked to mitoprotective and antioxidant properties of the plant. Mitochondrial dysfunction and oxidative stress are key drivers of aging and neurodegenerative disease, including Alzheimer's disease and Parkinson's disease. Here we appraise the growing body of evidence that the mitoprotective and antioxidative effects of CA may potentially be harnessed for the treatment of brain aging and neurodegenerative disease.

Study Type : Animal Study, In Vitro Study

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