Article Publish Status: FREE
Abstract Title:

Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial.

Abstract Source:

Nutrients. 2018 Dec 18 ;10(12). Epub 2018 Dec 18. PMID: 30567286

Abstract Author(s):

Almudena Sánchez-Villegas, Jacqueline Álvarez-Pérez, Estefanía Toledo, Jordi Salas-Salvadó, Carolina Ortega-Azorín, Maria Dolores Zomeño, Jesús Vioque, Jose Alfredo Martínez, Dora Romaguera, Jessica Pérez-López, José López-Miranda, Ramón Estruch, Aurora Bueno-Cavanillas, Fernando Arós, Josep A Tur, Francisco J Tinahones, Oscar Lecea, Vicente Martín, M Ortega-Calvo, Clotilde Vázquez, Xavier Pintó, Josep Vidal, Lidia Daimiel, Miguel Delgado-Rodríguez, Pilar Matía, Dolores Corella, Andrés Díaz-López, Nancy Babio, MiguelÁngel Muñoz, Montserrat Fitó, Manoli García de la Hera, Itziar Abete, Antonio García-Rios, Emilio Ros, Miguel Ruíz-Canela, MiguelÁngel Martínez-González, Marisol Izquierdo, Lluis Serra-Majem

Article Affiliation:

Almudena Sánchez-Villegas


BACKGROUND: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence.

METHODS: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption andω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms.

RESULTS: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, andfor trend = 0.759. Moderate intake of total LCω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression.

CONCLUSION: In our study, moderate fish and LCω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.

Study Type : Human Study

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