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Article Publish Status: FREE
Abstract Title:

Suppresses Inflammation and Glycolysis in Lipopolysaccharide-Activated RAW264.7 Macrophages.

Abstract Source:

Molecules. 2020 Aug 20 ;25(17). Epub 2020 Aug 20. PMID: 32825228

Abstract Author(s):

Shi Yan Lee, Won Fen Wong, Jiyang Dong, Kian-Kai Cheng

Article Affiliation:

Shi Yan Lee

Abstract:

Macrophage activation is a key event that triggers inflammatory response. The activation is accompanied by metabolic shift such as upregulated glucose metabolism. There are accumulating evidences showing the anti-inflammatory activity of. However, the effects ofon inflammatory response and glucose metabolism in activated macrophages have not been fully established. The present study aimed to examine the effect ofin modulating lipopolysaccharide (LPS)-induced inflammation and perturbed glucose metabolism in RAW264.7 murine macrophages. The results showed that LPS-induced NF-κB (p65) nuclear translocation was inhibited bytreatment. In addition,was found to reduce the expression of inflammatory genes including,α,β,,, andin LPS-treated macrophages. Furthermore, the data showed thatreduced the expression ofandgenes and lactate production (-28%), resulting in suppression of glycolysis. Notably, its effect ongene expression was found to be independent of LPS-induced inflammation. A further experiment also indicated that the bioactivities ofmay be attributed to its key bioactive compound, charantin. Taken together, the study provided supporting evidences showing the potential offor the treatment of inflammatory disorders.

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