Momordicinin showed potent α-amylase inhibitory activity. - GreenMedInfo Summary

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Abstract Title:

Isolation, characterisation and investigation ofantidiabetic and antioxidant activity of phytoconstituents from fruit ofLinn.

Abstract Source:

Nat Prod Res. 2019 Jul 2:1-3. Epub 2019 Jul 2. PMID: 31264459

Abstract Author(s):

Prajakta Kulkarni, Sathiyanarayanan Lohidasan, Kakasaheb Mahadik

Article Affiliation:

Prajakta Kulkarni

Abstract:

The dry powder of MC fruits was extracted by maceration, ultrasonication, liquid-liquid partition and soxhlation. Theantidiabetic and antioxidant assays were used to screen extracts and fractions. Refluxed and liquid partitioned extracts were fractionated using petroleum ether and ethyl acetate and purified with the help of preparative HPLC to give 2 phytoconstituents M1 and M2 respectively. Compound M1 (1) was identified as charantin and Compound M2 (2) was identified as momordicinin using spectral studies. Momordicinin showed potentα-amylase inhibitory activity with IC15.86μg/ml which was reported for the first time.

Article Published Date : Jul 01, 2019

Study Type : In Vitro Study

Additional Links

Substances : Bitter Melon : CK(254) : AC(112)

Diseases : Diabetes Mellitus: Type 2 : CK(8552) : AC(1714)

Pharmacological Actions : Alpha-amylase inhibitor : CK(175) : AC(110), Antioxidants : CK(21528) : AC(8856)

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Momordicinin showed potent α-amylase inhibitory activity. - GreenMedInfo Summary

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