Abstract Title:

Monosodium L-glutamate-induced convulsions--II. Changes in catecholamine concentrations in various brain areas of adult rats.

Abstract Source:

Gen Pharmacol. 1985 ;16(5):489-93. PMID: 4054574

Abstract Author(s):

C Beas-Zárate, J Arauz-Contreras, A Velazquez, A Feria-Velasco

Article Affiliation:

C Beas-Zárate


Norepinephrine (NE) and dopamine (DA) levels in various brain regions were measured in a model of experimentally produced convulsions by monosodium L-glutamate (MSG) administration to adult rats. Stress by injection of all solutions produced a 60% decrease in NE level in forebrain, recovering its basal value at 15 min after injection. A significant reduction of brain NE and DA levels of MSG-injected animals was found in the preconvulsive stage, particularly in the forebrain. No significant variations in catecholamine levels were seen in brain stem and cerebellum as a result of MSG injection. It is suggested that the changes found in endogenous catecholamine concentration in the forebrain may play a physiological role in the mechanisms of production of convulsions in the MSG model.

Study Type : Animal Study
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Anti Therapeutic Actions : Vaccination: All : CK(12676) : AC(1344)

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