Abstract Title:

Monosodium glutamate inhibits the lymphatic transport of lipids in the rat.

Abstract Source:

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 11:ajpgi.00342.2014. Epub 2016 Aug 11. PMID: 27514481

Abstract Author(s):

Alison B Kohan, Qing Yang, Min Xu, Dana Lee, Patrick Tso

Article Affiliation:

Alison B Kohan


It is not well understood of how monosodium glutamate affects gastrointestinal physiology, especially regarding the absorption and the subsequent transport of dietary lipids into lymph. Thus far, there is little information about how the ingestion of MSG affects the lipid lipolysis, uptake, intracellular esterification, and formation and secretion of chylomicrons. Using lymph fistula rats treated with the infusion of a 2% MSG prior solution prior to a continuous infusion of triglyceride, we show that MSG causes a significant decrease in both triglyceride and cholesterol secretion into lymph. Intriguingly, the diminished lymphatic transport of triglyceride and cholesterol was not caused by an accumulation of these labeled lipids in the intestinal lumen nor in the intestinal mucosa. Rather, it is a result of increased portal transport in the animals fed acutely the lipid plus 2% MSG in the lipid emulsion. This is a first demonstration of MSG on intestinal lymphatic transport of lipids.

Study Type : Animal Study

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Sayer Ji
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