Article Publish Status: FREE
Abstract Title:

Effect ofLeaf Powder on Postprandial Blood Glucose Response: In Vivo Study on Saharawi People Living in Refugee Camps.

Abstract Source:

Nutrients. 2018 Oct 12 ;10(10). Epub 2018 Oct 12. PMID: 30322091

Abstract Author(s):

Alessandro Leone, Simona Bertoli, Sara Di Lello, Angela Bassoli, Stefano Ravasenghi, Gigliola Borgonovo, Fabio Forlani, Alberto Battezzati

Article Affiliation:

Alessandro Leone


The hypoglycemic effect in humans of(MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibitα-amylase activity, and its sensory acceptability in food. We then evaluated its effect on postprandial glucose response by randomly administering, on 2 different days, a traditional meal supplemented with 20 g of MO leaf powder (MOR20), or not (control meal, CNT), to 17 Saharawi diabetics and 10 healthy subjects. Capillary glycaemia was measured immediately before the meal and then at 30 min intervals for 3 h. In the diabetic subjects the postprandial glucose response peaked earlier with MOR20 compared to CNT and with lower increments at 90, 120, and 150 min. The mean glycemic meal responsewith MOR20 was lower than with CNT. The healthy subjects showed no differences. Thus, MO leaf powder could be a hypoglycemic herbal drug. However, given the poor taste acceptability of the 20 g MO meal, lower doses should be evaluated. Moreover, the hypoglycemic effects of MO leaf powder should alsobe demonstrated by trials evaluating its long-term effects on glycaemia.

Study Type : Human Study

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