Abstract Title:

Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract.

Abstract Source:

Cell Mol Biol (Noisy-le-grand). 2016 Mar 31 ;62(3):72-7. Epub 2016 Mar 31. PMID: 27064876

Abstract Author(s):

S Fallah, A Karimi, G Panahi, S Gerayesh Nejad, R Fadaei, M Seifi

Article Affiliation:

S Fallah


The mechanistic basis for the biological properties of Morus alba flavonoid extract (MFE) and chemotherapy drug of doxorubicin on human colon cancer HT-29 cell line death are unknown. The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated. The results showed that flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line. MFE and doxorubicin exert a cytotoxic effect on human colon cancer HT-29 cell line by probably promoting or induction of apoptosis.

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