Abstract Title:

Antiviral flavonoids from Mosla scabra.

Abstract Source:

Fitoterapia. 2009 Dec 13. Epub 2009 Dec 13. PMID: 20006976

Abstract Author(s):

Qiaofeng Wu, Chenhuan Yu, Yunliang Yan, Jing Chen, Chunchun Zhang, Xinxin Wen

Article Affiliation:

College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China.


An ethanolic extract and ethyl acetate fraction (EFMS) prepared from Mosla scabra showed potential inhibition against influenza viruses. The compounds isolated from EFMS were elucidated to be ursolic acid (1), 5-hydroxy-6,7-dimethoxyflavone (2), 5-hydroxy-7,8-dimethoxyflavone (3), apigenin (4) and acacetin (5) based on their spectral analysis. Compounds 2, 3, 4 and 5 showed significant anti-influenza viruses activities. Compared with ribavirin, EFMS appeared to have similar efficacy against influenza viruses, was considered to be less toxic and may warrant further evaluation as a possible agent for the treatment of influenza.

Study Type : In Vitro Study

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