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Article Publish Status: FREE
Abstract Title:

Mulberry and-based solid beverage promotes weight loss in rats by antagonizing white adipose tissue PPARγand FGFR1 signaling.

Abstract Source:

Front Endocrinol (Lausanne). 2024 ;15:1344262. Epub 2024 Mar 15. PMID: 38559696

Abstract Author(s):

Xiao-Ting Zhou, An-Qi Zhu, Xiao-Min Li, Ling-Yue Sun, Jian-Gang Yan, Nin Luo, Shi-Sheng Chen, Zebo Huang, Xin-Liang Mao, Kun-Ping Li

Article Affiliation:

Xiao-Ting Zhou

Abstract:

Obesity, a multifactorial disease with many complications, has become a global epidemic. Weight management, including dietary supplementation, has been confirmed to provide relevant health benefits. However, experimental evidence and mechanistic elucidation of dietary supplements in this regard are limited. Here, the weight loss efficacy of MHP, a commercial solid beverage consisting of mulberry leaf aqueous extract andprotein peptides, was evaluated in a high-fat high-fructose (HFF) diet-induced rat model of obesity. Body component analysis and histopathologic examination confirmed that MHP was effective to facilitate weight loss and adiposity decrease. Pathway enrichment analysis with differential metabolites generated by serum metabolomic profiling suggests that PPAR signal pathway was significantly altered when the rats were challenged by HFF diet but it was rectified after MHP intervention. RNA-Seq based transcriptome data also indicates that MHP intervention rectified the alterations of white adipose tissue mRNA expressions in HFF-induced obese rats. Integrated omics reveals that the efficacy of MHP against obesogenic adipogenesis was potentially associated with its regulation of PPARγand FGFR1 signaling pathway. Collectively, our findings suggest that MHP could improve obesity, providing an insight into the use of MHP in body weight management.

Study Type : Animal Study

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