Article Publish Status: FREE
Abstract Title:

Anti-anxiety and Anti-depressant Like Effects ofin Experimental Models of Anxiety and Depression.

Abstract Source:

Anc Sci Life. 2017 Apr-Jun;36(4):215-219. PMID: 29269974

Abstract Author(s):

Snigdha Sharma, Shailendra Handu, Ashok Kumar Dubey, Prashant Sharma, Pramod Mediratta, Qazi Mushtaq Ahmed

Article Affiliation:

Snigdha Sharma


Background: Presence of free radical scavenging activity in, commonly known as Curry leaves, has been shown in previous studies. Oxidative stress plays an important role in the development of various neurobehavioral disorders including anxiety and depression.

Aim: The present study aimed to evaluate the effects ofin animal models of depression and anxiety.

Materials and Methods: The effect of incremental doses ofaqueous leaf extract was evaluated on spontaneous motor activity (SMA), open arm incursions in elevated plus maze, and despair behaviour in forced swim (FST) and tail suspension (TST) tests as compared to control groups in Swiss albino mice.

Results: 300 mg/kg, p.o. (MK300) and 400 mg/kg, p.o. (MK400) reduced the SMA count from 754± 64.9 to 540 ± 29 and 295 ± 34 respectively, which was statistically significant. MK300 and MK400 reduced significantly the open arm count from 29 ± 8.6 to 16 ± 7 and 10 ± 3.9, respectively. On FST, MK400 reduced the duration of immobility from 145.5 ± 29 to 91 ± 17.3, which was statistically significant. On TST, MK produced a dose-dependent decrease in the duration of immobility; however, it was statistically significant only with MK400.

Conclusion: aqueous leaf extract reduced the despair behavior in experimental animal models, suggesting an anti-depressant like activity.extract also reduced spontaneous locomotor activity in a dose-dependent manner suggesting a sedative and/or anxiolytic effect though there wasn't any anxiolytic effect in the elevated plus maze test.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.