Abstract Title:

Protective effects of mustard leaf (Brassica juncea) against diabetic oxidative stress.

Abstract Source:

J Nutr Sci Vitaminol (Tokyo). 2003 Apr;49(2):87-93. PMID: 12887153

Abstract Author(s):

Takako Yokozawa, Hyun Young Kim Kim, Eun Ju Cho, Noriko Yamabi, Jae Sue Choi


Of four fractions (CH2Cl2, EtOAc, BuOH and H2O) from mustard leaf (Brassica juncea), the EtOAc fraction showed the strongest inhibitory effects, which were concentration-dependent, on the formation of advanced glycation end products and free radical-mediated protein damage in an in vitro system, indicating that this fraction has a potential protective role against diabetes and/or its complications. Based on these results, we carried out an in vivo study to determine whether the EtOAc fraction protected against diabetic oxidative stress induced by streptozotocin. Oral administration of the EtOAc fraction at doses of 50 and 200 mg/kg body weight/d for 10 d reduced the serum levels of glucose and glycosylated protein, implying that the impaired glucose metabolism due to diabetes had been ameliorated. In addition, the EtOAc fraction significantly reduced the thiobarbituric acid-reactive substance levels of serum and hepatic and renal mitochondria. Furthermore, the elevated levels of superoxide and nitrite/nitrate were reduced in a dose-dependent manner by oral administration of the EtOAc fraction. These findings suggest that the EtOAc fraction from mustard leaf might be beneficial in attenuating the damage caused by oxidative stress involved in diabetes and its complications.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.