Article Publish Status: FREE
Abstract Title:

A Natural Dietary Flavone Myricetin as anα-Hemolysin Inhibitor for ControllingInfection.

Abstract Source:

Front Cell Infect Microbiol. 2020 ;10:330. Epub 2020 Jul 23. PMID: 32793508

Abstract Author(s):

Tingting Wang, Peng Zhang, Hongfa Lv, Xuming Deng, Jianfeng Wang

Article Affiliation:

Tingting Wang


, an important agent for lethal bacterial infections, can cause a broad spectrum of diseases in various host species. The emergence of multidrug-resistant and highly virulent strains has raised increasing concerns about the novel therapeutic strategies or agents available for treatinginfection. The critical role of Hla, an essential virulence determinant, in the pathogenicity ofrenders this toxin an attractive target for effective therapeutic applications. Here, we have identified myricetin as an effective inhibitor of Hla that simultaneously inhibits Hla production and neutralizes Hla activity without affecting bacterial growth. Myricetin treatment reduced the oligomerization of Hla and Hla-mediated biofilm formation. The addition of myricetin to the coinfection system of host cells andsignificantly decreased cell injury and downregulated the inflammatory response in cells. Furthermore,-infected mice that received myricetin showed alleviated tissue damage in the lung. Our results indicated that myricetin inhibitsvirulence by targeting Hla and downregulates the inflammatory response in host cells. Overall, in addition to traditional antibiotics with antibacterial activity, myricetin may represent a potential candidate, and strategy forinfection.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.