Myricetin may represent a potential candidate and strategy for S. aureus infection. - GreenMedInfo Summary
A Natural Dietary Flavone Myricetin as anα-Hemolysin Inhibitor for ControllingInfection.
Front Cell Infect Microbiol. 2020 ;10:330. Epub 2020 Jul 23. PMID: 32793508
, an important agent for lethal bacterial infections, can cause a broad spectrum of diseases in various host species. The emergence of multidrug-resistant and highly virulent strains has raised increasing concerns about the novel therapeutic strategies or agents available for treatinginfection. The critical role of Hla, an essential virulence determinant, in the pathogenicity ofrenders this toxin an attractive target for effective therapeutic applications. Here, we have identified myricetin as an effective inhibitor of Hla that simultaneously inhibits Hla production and neutralizes Hla activity without affecting bacterial growth. Myricetin treatment reduced the oligomerization of Hla and Hla-mediated biofilm formation. The addition of myricetin to the coinfection system of host cells andsignificantly decreased cell injury and downregulated the inflammatory response in cells. Furthermore,-infected mice that received myricetin showed alleviated tissue damage in the lung. Our results indicated that myricetin inhibitsvirulence by targeting Hla and downregulates the inflammatory response in host cells. Overall, in addition to traditional antibiotics with antibacterial activity, myricetin may represent a potential candidate, and strategy forinfection.