Abstract Title:

The enhancement of N-acetylcysteine on intestinal absorption and oral bioavailability of hydrophobic curcumin.

Abstract Source:

Eur J Pharm Sci. 2020 Aug 5 ;154:105506. Epub 2020 Aug 5. PMID: 32763460

Abstract Author(s):

Shanshan Zhang, Sajid Asghar, Feng Yu, Ziyi Hu, Qineng Ping, Zhipeng Chen, Feng Shao, Yanyu Xiao

Article Affiliation:

Shanshan Zhang


To solve the low oral bioavailability of curcumin (CUR) due to the limits imposed by gastrointestinal (GI) barrier, we constructed a nano delivery system to evaluate the effect of N-acetyl-L-cysteine (NAC) on intestinal absorption and oral bioavailability of CUR. CUR was first encapsulated in bovine serum albumin nanoparticles (CUR-BSA-NPs), and then was further modified by NAC (CUR-NBSA-NPs). In situ single-pass intestinal perfusion assay demonstrated that CUR-NBSA-NPs displayed excellent permeation and absorption rates in GI tract. Additionally, the distribution study in GI tract revealed that more NBSA-NPs were absorbed by intestinal segments compared to the BSA nanoparticles. Plasma concentration-time curves in rats showed that AUC, Cand MRTvalues of CUR after oral administration of CUR-NBSA-NPs were increased to 3.25-, 4.42-, and 1.43-fold compared with that of CUR suspension. In conclusion, NAC promotes oral absorption of CUR, thereby improving its oral bioavailability.

Study Type : In Vitro Study

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