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Abstract Title:

N-Acetylcysteine Reduces miR-146a and NF-κB p65 Inflammatory Signaling Following Cadmium Hepatotoxicity in Rats.

Abstract Source:

Biol Trace Elem Res. 2021 Jan 17. Epub 2021 Jan 17. PMID: 33454892

Abstract Author(s):

Rasha S Albeltagy, Farah Mumtaz, Ahmed E Abdel Moneim, Ola H El-Habit

Article Affiliation:

Rasha S Albeltagy

Abstract:

We performed a thorough screening and analysis of the impact of cadmium chloride (CdCl) and N-acetylcysteine (NAC) on the miR146a/NF-κB p65 inflammatory pathway and mitochondrial biogenesis dysfunction in male albino rats. A total of 24 male albino rats were divided into three groups: a control group, a CdCl-treated group (3 mg/kg, orally), and a CdCl+ NAC-treated group (200 mg/kg of NAC, 1 h after CdCltreatment), for 60 consecutive days. Real-time quantitative PCR was used to analyze the expression of miR146a, Irak1, Traf6, Nrf1, Nfe2l2, Pparg, Prkaa, Stat3, Tfam, Tnfa, and Il1b, whereas tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 protein levels were assessed using ELISA, and NF-κB p65 was detected using western blotting. A significant restoration of homeostatic inflammatory processes as well as mitochondrial biogenesis was observed after NAC and CdCltreatment. Decreased miR146a and NF-κB p65 were also found after treatment with NAC and CdClcompared with CdCltreatment alone. Collectively, our findings demonstrate that CdClcaused mtDNA release because of Tfam loss, leading to NF-κB p65 activation. Co-treatment with NAC could alleviate Cd-induced genotoxicity in liver tissue. We concluded that adding NAC to CdClresulted in a decreased signaling of the NF-κB p65 signaling pathway.

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