n/a
Article Publish Status: FREE
Abstract Title:

Safety and efficacy of N-acetyl-cysteine for prophylaxis of ventilator-associated pneumonia: a randomized, double blind, placebo-controlled clinical trial.

Abstract Source:

Med Gas Res. 2018 Jan-Mar;8(1):19-23. Epub 2018 Apr 18. PMID: 29770192

Abstract Author(s):

Mojtaba Sharafkhah, Ali Abdolrazaghnejad, Nader Zarinfar, Abolfazl Mohammadbeigi, Ali Massoudifar, Sahand Abaszadeh

Article Affiliation:

Mojtaba Sharafkhah

Abstract:

Ventilator-associated-pneumonia (VAP) is characterized by morbidity, mortality, and prolonged length of stay in intensive care unit (ICU). The present study aimed to examine the effect of N-acetyl-cysteine (NAC) in preventing VAP in patients hospitalized in ICU. We performed a prospective, randomized, double-blind, placebo-controlled trial of 60 mechanically ventilated patients at high risk of developing VAP. NAC (600 mg/twice daily) and placebo (twice daily) were administered to NAC group (= 30) and control group (= 30), respectively, through the nasogastric tube in addition to routine care. The clinical response was considered as primary (incidence of VAP) and secondary outcomes. Twenty-two (36.6%) patients developed VAP. Patients treated with NAC were significantly less likely to develop clinically confirmed VAP compared with patients treated with placebo (26.6%. 46.6%;= 0.032). Patients treated with NAC had significantly less ICU length of stay (14.36± 4.69 days. 17.81± 6.37 days,= 0.028) and less hospital stay (19.23± 5.54 days. 24.61± 6.81 days;= 0.03) than patients treated with placebo. Time to VAP was significantly longer in the NAC group (9.42± 1.9 days. 6.46± 2.53 days;= 0.002). The incidence of complete recovery was significantly higher in the NAC group (56.6%. 30%;= 0.006). No adverse events related to NAC were identified. NAC is safe and effective to prevent and delay VAP, and improve its complete recovery rate in a selected, high-risk ICU population.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.