Nano-encapsulated Tinospora cordifolia educe effective control in streptozotocin-induced type 2 diabetes. - GreenMedInfo Summary

n/a
Abstract Title:

Nano-encapsulated(Willd.) using poly (D, L-lactide) nanoparticles educe effective control in streptozotocin-induced type 2 diabetic rats.

Abstract Source:

IET Nanobiotechnol. 2020 Dec ;14(9):803-808. PMID: 33399111

Abstract Author(s):

Ragavee Ambalavanan, Arul Daniel John, Asha Devi Selvaraj

Article Affiliation:

Ragavee Ambalavanan

Abstract:

The therapeutics for type 2 diabetes mellitus has emerged in the current century towards nanomedicine incorporated with plant active compounds. In this study,loaded poly (D, L-lactide) (PLA) nanoparticles (NPs) were evaluated in vivo for their anti-hyperglycemic potency towards streptozotocin-induced type 2 diabetic rats.loaded PLA NPs were synthesised by the double solvent evaporation method using PLA polymer. The NPs were then characterised and administrated orally for 28 successive days to streptozotocin-induced diabetic rats. The PLA NPs had significant anti-diabetic effects which were equal to the existing anti-diabetic drug glibenclamide. The antidiabetic activity is due to the synergism of compounds present in stem extract of the plant which reduced the side effects and anti-diabetic.

Article Published Date : Nov 30, 2020
Study Type : Animal Study
Additional Links
Substances : Guduchi : CK(241) : AC(89)
Diseases : Diabetes Mellitus: Type 2 : CK(8552) : AC(2358)
Pharmacological Actions : Hypoglycemic Agents : CK(5366) : AC(1911)
Additional Keywords : Natural Substances Versus Drugs : CK(2375) : AC(549)

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Key Research Topics

Disease

Diabetes Mellitus: Type 2

Pharmacological Actions

Hypoglycemic Agents

Substance

Guduchi

Connect with GreenMedInfo

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.