Abstract Title:

Efficacy of some colloidal silver preparations and silver salts against Proteus bacteria, one possible cause of rheumatoid arthritis.

Abstract Source:

Inflammopharmacology. 2014 Apr ;22(2):73-7. Epub 2014 Jan 5. PMID: 24390313

Abstract Author(s):

D M B T Disaanayake, Joan Faoagali, Hans Laroo, Gerald Hancock, Michael Whitehouse

Article Affiliation:

D M B T Disaanayake


There has been increased interest in the role of anti-Proteus antibodies in the aetiology of rheumatoid arthritis (RA) and whether chemotherapeutic agents active against Proteus species might reduce the risk and/or exacerbations of RA. We examined the in vitro antibacterial effects of ten different silver preparations which were either ionic silver [Ag(I)] solutions or nanoparticulate silver (NPS) (Ag(0)) suspensions against ATCC and two wild (clinical) strains of Proteus. The data establish the low minimum inhibitory concentration and minimum bactericidal concentration of all the silver formulations tested against these four Proteus strains. In a pilot study, a potent NPS preparation ex vivo showed long-lasting anti-Proteus activity in a normal human volunteer.

Study Type : Human: Case Report, In Vitro Study

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