Abstract Title:

Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells.

Abstract Source:

Nanomedicine (Lond). 2010 Oct;5(8):1193-203. PMID: 21039197

Abstract Author(s):

Ilham F Osman, Adolf Baumgartner, Eduardo Cemeli, Jonathan N Fletcher, Diana Anderson

Article Affiliation:

Division of Biomedical Sciences, University of Bradford, Richmond Road, Bradford, West Yorkshire, BD7 1DP, UK.


AIMS: The rapidly growing industrial and medical use of nanomaterials, especially zinc oxide and titanium dioxide, has led to growing concerns about their toxicity. Accordingly, the intrinsic genotoxic and cytotoxic potential of these nanoparticles have been evaluated. MATERIALS&METHODS: Using a HEp-2 cell line, cytotoxicity was tested along with mitochondrial activity and neutral red uptake assays. The genotoxic potential was determined using the Comet and the cytokinesis-blocked micronucleus assays. In addition, tyrosine phosphorylation events were investigated. RESULTS&CONCLUSION: We found concentration- and time-dependent cytotoxicity and an increase in DNA and cytogenetic damage with increasing nanoparticle concentrations. Mainly for zinc oxide, genotoxicity was clearly associated with an increase in tyrosine phosphorylation. Our results suggest that both types of nanoparticles can be genotoxic over a range of concentrations without being cytotoxic.

Study Type : In Vitro Study
Additional Links
Anti Therapeutic Actions : Nanotechnology : CK(70) : AC(0)
Adverse Pharmacological Actions : Genotoxic : CK(540) : AC(179)

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