Abstract Title:

Naringenin mitigates titanium dioxide (TiO)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB.

Abstract Source:

Inflamm Res. 2018 Dec ;67(11-12):997-1012. Epub 2018 Oct 28. PMID: 30370484

Abstract Author(s):

Marília F Manchope, Nayara A Artero, Victor Fattori, Sandra S Mizokami, Dimitrius L Pitol, João P M Issa, Sandra Y Fukada, Thiago M Cunha, José C Alves-Filho, Fernando Q Cunha, Rubia Casagrande, Waldiceu A Verri

Article Affiliation:

Marília F Manchope


OBJECTIVE: To evaluate the effect and mechanisms of naringenin in TiO-induced chronic arthritis in mice, a model resembling prosthesis and implant inflammation.

TREATMENT: Flavonoids are antioxidant and anti-inflammatory molecules with important anti-inflammatory effect. Mice were daily treated with the flavonoid naringenin (16.7-150 mg/kg, orally) for 30 days starting 24 h after intra-articular knee injection of 3 mg of TiO.

METHODS: TiO-induced arthritis resembles cases of aseptic inflammation induced by prosthesis and/or implants. Mice were stimulated with 3 mg of TiOand after 24 h mice started to be treated with naringenin. The disease phenotype, treatment toxicity, histopathological damage, oxidative stress, cytokine expression and NFκB were evaluated after 30 days of treatment.

RESULTS: Naringenin inhibited TiO-induced mechanical hyperalgesia (96%), edema (77%) and leukocyte recruitment (74%) without inducing toxicity. Naringenin inhibited histopathological index (HE, 49%), cartilage damage (Toluidine blue tibial staining 49%, and proteoglycan 98%), and bone resorption (TRAP-stained 73%). These effects were accompanied by inhibition of oxidative stress (gp9193%, NBT 83%, and TBARS 41%) cytokine mRNA expression (IL-33 82%, TNFα 76%, pro-IL-1β 100%, and IL-6 61%), and NFκB activation (100%).

CONCLUSION: Naringenin ameliorates TiO-induced chronic arthritis inducing analgesic and anti-inflammatory responses with improvement in the histopathological index, cartilage damage, and bone resorption.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.