Abstract Title:

Naringin abates adverse effects of cadmium-mediated hepatotoxicity: An experimental study using HepG2 cells.

Abstract Source:

J Biochem Mol Toxicol. 2017 Aug ;31(8). Epub 2017 Apr 19. PMID: 28422390

Abstract Author(s):

Visesh Kumar Rathi, Shubhankar Das, Archana Parampalli Raghavendra, Bola Sadashiva Satish Rao

Article Affiliation:

Visesh Kumar Rathi


This study investigated the protective potential of Naringin (NIN) against cadmium chloride (CdCl) mediated hepatotoxicity using human hepatocellular carcinoma (HepG2) cells. An optimal concentration of NIN (5 μM) was potent enough to confer cytoprotection against CdCl(50 μM) as was observed by MTT assay. Preconditioning with NIN maintained redox homeostasis, mitochondrial membrane potential, and reduced apoptosis as marked by decrease in the percentage sub-G/Gand Annexin V-FITC/propidium iodide positive cells (apoptotic). NIN pretreatment maintained the levels of protein thiol along with endogenous activities of Superoxide dismutase, Glutathione S-transferase, and Catalase and lowered lipid peroxidation. Decreased Bax/Bcl2 ratio along with reduced Caspase 3 cleavage and Cytochrome c release indicated that NIN conditioning blocked mitochondrial-mediated apoptosis. Increased Nrf2 and metallothionein (MT) acted as adaptive response in the presence of cadmium. Thus, the protective mechanism of NIN is attributed to its antioxidant potential which aids in redox homeostasis and prevents CdClmediated cytotoxicity.

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