Article Publish Status: FREE
Abstract Title:

Effect of Naringin Treatment on Postmenopausal Osteoporosis in Ovariectomized Rats: A Meta-Analysis and Systematic Review.

Abstract Source:

Evid Based Complement Alternat Med. 2021 ;2021:6016874. Epub 2021 Feb 10. PMID: 33628301

Abstract Author(s):

Zhu Zhu, Wenjing Xie, Yanyan Li, Zaiou Zhu, Wei Zhang

Article Affiliation:

Zhu Zhu


Background: Osteoporosis is a major disease that affects the quality of life of middle-aged and old people, so it is very important to find efficient and safe drugs to treat osteoporosis. The purpose of this study was to investigate the therapeutic effect of naringin on postmenopausal osteoporosis in ovariectomized (OVX) rats.

Methods: Chinese biomedical databases, CNKI, PubMed, EMBASE, and Wan Fang were searched for articles from inception to March 2020. Two independent researchers screened articles according to inclusion criteria. RevMan 5.3 was used for data analysis.

Results: Ten studies were included in the systematic review. The bone mineral density (BMD) significantly increased after naringin treatment (weighted mean difference, 0.06; 95% CI, 0.03-0.09; < 0.01). There was no significant increase in BMD after estrogen treatment compared with naringin (weighted mean difference, 0.00; 95% CI, -0.00 to 0.01; = 0.06). The trabecular bone volume (BV/TV) (weighted mean difference, 2.09; 95% CI, 1.85-2.34; < 0.01) and trabecular thickness (Tb.Th) (weighted mean difference, 6.65; 95% CI, 6.55-6.74; < 0.01) significantly increased after using naringin.

Conclusions: Naringin had been shown to promote bone formation in OVX rats. However, the mechanism of naringin needs more research to confirm.

Study Type : Meta Analysis, Review

Print Options

Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.