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Abstract Title:

Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

Abstract Source:

Chem Biol Interact. 2017 Jan 5 ;261:11-17. Epub 2016 Nov 8. PMID: 27833010

Abstract Author(s):

Nan Song, Zhihu Zhao, Xinlong Ma, Xiaolei Sun, Jianxiong Ma, Fengbo Li, Lei Sun, Jianwei Lv

Article Affiliation:

Nan Song

Abstract:

Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear. Here, we show that naringin promotes fracture healing through stimulating angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.

Study Type : Animal Study

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