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Article Publish Status: FREE
Abstract Title:

Saffron (L.) in Ocular Diseases: A Narrative Review of the Existing Evidence from Clinical Studies.

Abstract Source:

Nutrients. 2019 Mar 18 ;11(3). Epub 2019 Mar 18. PMID: 30889784

Abstract Author(s):

Rebekka Heitmar, James Brown, Ioannis Kyrou

Article Affiliation:

Rebekka Heitmar

Abstract:

Saffron (L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.

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