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Abstract Title:

Near-infrared irradiation controlled thermo-switchable polymeric photosensitizer againstβ-amyloid fibrillation.

Abstract Source:

J Mater Chem B. 2022 06 29 ;10(25):4832-4839. Epub 2022 Jun 29. PMID: 35674394

Abstract Author(s):

Li Chen, Zhe Zhou, Yuexing Zhang, Jie Pan, Kai Wang, Hang-Xing Wang

Article Affiliation:

Li Chen

Abstract:

Photothermal therapy (PTT) is an emerging paradigm for the degradation of amyloid-β (Aβ) aggregations and has become an effective way of treating Alzheimer's disease (AD). A promising PTT therapeutic option requires control of at least two key functional aspects: controllable photoactivity and specific activation. In this work, a near-infrared (NIR)-activated thermo-switchablebiopolymeric PTT agent was designed and synthesized by conjugating a molecular rotor-based boron dipyrromethene photosensitizer (BDP) to a temperature-responsive polymer backbone of biopolymeric hydroxypropyl cellulose (HPC). The as-synthesized BDP-HPC exhibited an ultra-high PCE of 78.1% along withprominent cycling stability of phase-transition behavior under NIR irradiation in the light of the lower critical solution temperature (LCST at 42.5 °C). Importantly, the NIR irradiation can manipulate the reversible phase transition behavior of the resultant BDP-HPC that reveals high effectiveness in inhibiting Aβ aggregation together with the obvious ability to dissociate Aβ aggregations. Our work reveals an accurate modulation strategy for versatile and high-performance AD treatment.

Study Type : In Vitro Study

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