Neonatal exposure to bisphenol A advances pubertal development in female rats. - GreenMedInfo Summary
Neonatal exposure to bisphenol A advances pubertal development in female rats.
Mol Reprod Dev. 2020 Feb 28. Epub 2020 Feb 28. PMID: 32109339
Neonatal exposure to bisphenol A (BPA) is hypothesized to advance pubertal development. However, the effects of neonatal BPA exposure on pubertal development has not been described. In this study, female Sprague-Dawley rats were exposed to 0.05, 0.5, 5, or 10 mg·kg·dayBPA, or corn oil vehicle alone from postnatal day 1 (PND1) to PND10 via subcutaneous injection. We evaluated day of vaginal opening (DVO), ovarian morphology, serum hormone concentrations, and hypothalamic expression of Gnrh1 and Kiss1 in female rats at PND35. DVO was significantly advanced in rats exposed to 5 and 10 mg·kg·dayBPA. Serum hormone concentrations increased as BPA dose increased. Additionally, hypothalamic Gnrh1 and Kiss1 expression were increased with BPA exposure; rats exposed to 10 mg·kg·dayBPA had significantly upregulated hypothalamic Gnrh1 and Kiss1 expressions in terms of both messenger RNA and protein levels. Our results suggest that exposure to a 10 mg·kg·daydose of BPA might advance pubertal development significantly. In addition, within the range of 0 to 10 mg·kg·day, neonatal exposure to BPA may affect pubertal development in a dose-dependent manner.