Abstract Title:

Aqueous extract of Urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer.

Abstract Source:

Vaccine. 2007 Feb 26;25(10):1838-40. Epub 2006 Nov 9. PMID: 15254411

Abstract Author(s):

Ilker Durak, Hasan Biri, Erdinç Devrim, Sinan Sözen, Aslihan Avci

Abstract:

AIM: Investigation of possible effects of aqueous extract of Urtica dioica leaves on adenosine deaminase activity in prostate tissue from patients with prostate cancer. METHODS: Ten prostate tissues from patients with pathologically proven localized prostate cancer (Gleason scores 4 to 7) were used in the study. In the tissues, ADA activities with and without preincubation with different amounts of Urtica dioica extracts were performed. RESULTS: Aqueous extract of Urtica dioica results in significant inhibition on adenosine deaminase (ADA) activity of prostate tissue. CONCLUSION: ADA inhibition by Urtica dioica extract might be one of the mechanisms in the observed beneficial effect of Urtica dioica in prostate cancer.

Study Type : In Vitro Study

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