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Abstract Title:

Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer's disease.

Abstract Source:

Biosci Biotechnol Biochem. 2018 Jan ;82(1):57-64. Epub 2017 Dec 1. PMID: 29191087

Abstract Author(s):

Hong-Xin Fei, Ying-Bo Zhang, Ting Liu, Xiao-Jie Zhang, Shu-Liang Wu

Article Affiliation:

Hong-Xin Fei

Abstract:

Alzheimer's disease (AD) is the most common cause of dementia among elderly population. Derangedβ-amyloid (Aβ) trafficking across the blood-brain barrier is known to be a critical element in the pathogenesis of AD. In the vascular endothelial cells of hippocampus, Aβ transport is mainly mediated by low-density lipoprotein-associated protein 1 (LRP1) and the receptor for advanced glycation end (RAGE) products; therefore, LRP1 and RAGE endothelial cells are potential therapeutic targets for AD. In this study, we explored the effects of Formononetin (FMN) on learning and memory improvement in APP/PS1 mice and the related mechanisms. We found that FMN significantly improved learning and memory ability by suppressing Aβ production from APP processing, RAGE-dependent inflammatory signaling and promoted LRP1-dependent cerebral Aβ clearance pathway. Moreover, FMN treatment alleviated ultrastructural changes in hippocampal vascular endothelial cells. In conclusion, we believe that FMNmay be an efficacious and promising treatment for AD.

Study Type : Animal Study

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Sayer Ji
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