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Abstract Title:

Neuroprotective effects of curcumin through autophagy modulation.

Abstract Source:

IUBMB Life. 2019 Dec 5. Epub 2019 Dec 5. PMID: 31804772

Abstract Author(s):

Fatemeh Forouzanfar, Morgayn I Read, George E Barreto, Amirhossein Sahebkar

Article Affiliation:

Fatemeh Forouzanfar

Abstract:

Autophagy is a highly conserved cellular degradation process involving lysosomal degradation for the turnover of proteins, protein complexes, and organelles. Defects in autophagy produces impaired intercellular communication and have subsequently been shown to be associated with pathological conditions, including neurodegenerative diseases. Curcumin is a polyphenol found in the rhizome of Curcuma longa, which has been shown to exert health benefits, such as antimicrobial, antioxidant, anti-inflammatory, and anticancer effects. There is increasing evidence in the literature revealing that autophagy modulation may provide neuroprotective effects. In light of this, our current review aims to address recent advances in the neuroprotective role of curcumin-induced autophagy modulation, specifically with a particular focus on its effects in Alexander disease, Alzheimer's disease, ischemia stroke, traumatic brain injury, and Parkinson's disease.

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