Neuroprotective effects of Morinda officinalis How.: anti-inflammatory and antioxidant roles in Alzheimer's disease. - GreenMedInfo Summary
Neuroprotective effects ofHow.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
Front Aging Neurosci. 2022 ;14:963041. Epub 2022 Sep 8. PMID: 36158563
Yi Zhang
Pharmacological studies have shown that some traditional Chinese medicines (TCMs) have applications in the treatment of Alzheimer's disease (AD).How. (MO) is a TCM with a long history and is widely used to tonify kidney Yang.andexperiments have suggested that MO contains various effective pharmaceutical components and chemicals, including oligosaccharides, anthraquinones, iridoids, flavonoids, amino acids, and trace elements, conferring MO with anti-inflammatory and antioxidant properties. Neuroinflammation and oxidative stress are undoubtedly hallmarks of neurodegeneration, contributing to AD progression. In this mini-review, we summarize the molecular mechanisms, structure-activity relationships, and potential synergistic and antagonistic effects of active components in MO. This discussion highlights the roles of these active components, such as oligosaccharides, anthraquinones, and iridoid glycosides, in the treatment of ADanti-inflammatory and antioxidant mechanisms, providing a scientific basis for further utilization of MO.