n/a
Abstract Title:

Neuroprotective effects of pretreatment of ginsenoside Rb1 on severe cerebral ischemia-induced injuries in aged mice: Involvement of anti-oxidant signaling.

Abstract Source:

Geriatr Gerontol Int. 2017 Feb ;17(2):338-345. Epub 2015 Dec 29. PMID: 26712031

Abstract Author(s):

Xiao Dong, Lei Zheng, Shujing Lu, Yanbei Yang

Article Affiliation:

Xiao Dong

Abstract:

AIM: Ginsenosides, a class of ginseng compounds of herbal medicine, have been shown to have therapeutic potential for the neuroprotection of brain damage after cerebral ischemia because of their activities including anti-oxidant and anti-inflammation. In the elderly population, aging-induced oxidative stress has been implicated in exacerbating brain injury, which might also be ameliorated by anti-oxidants, such as ginsenosides. However, this hypothesis has yet to be explored.

METHODS: Here we present in vivo studies highlighting a protective function of ginsenoside Rb1, a natural steroid glycoside derivative purified from saponin of Panax ginseng, in neurological injury during aging.

RESULTS: Compared with young mice, the recovery of brain damage after middle cerebral artery occlusion is significantly impaired in aged mice, whereas the long-term pretreatment with ginsenoside Rb1 through oral administration can greatly prevent the injury in a dose-dependent manner. In addition, we further explored the involvement of oxidative stress and extracellular signal-regulated kinase activation in aged mice stimulated by cerebral ischemia, both of which were found to be blocked by ginsenoside Rb1.

CONCLUSIONS: These observations suggest that ginsenoside Rb1 could represent promising applications as anti-oxidants for the anti-aging treatment of neurological disorders, such as stroke, in elderly patients. Geriatr Gerontol Int 2017; 17: 338-345.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.