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Abstract Title:

Neuroprotective effects of rutin on ASH neurons inmodel of Huntington's disease.

Abstract Source:

Nutr Neurosci. 2021 Jul 26:1-14. Epub 2021 Jul 26. PMID: 34311678

Abstract Author(s):

Larissa Marafiga Cordeiro, Marcell Valandro Soares, Aline Franzen da Silva, Marina Lopes Machado, Fabiane Bicca Obetine Baptista, Tássia Limana da Silveira, Leticia Priscilla Arantes, Felix Alexandre Antunes Soares

Article Affiliation:

Larissa Marafiga Cordeiro

Abstract:

Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disease. It occurs due to a mutated huntingtin gene that contains an abnormal expansion of cytosine-adenine-guanine repeats, leading to a variable-length N-terminal polyglutamine (polyQ) chain. The mutation confers toxic functions to mutant huntingtin protein, causing neurodegeneration. Rutin is a flavonoid found in various plants, such as buckwheat, some teas, and apples. Our previous studies have indicated that rutin has protective effects in HD models, but more studies are needed to unravel its effects on protein homeostasis, and to discern the underlying mechanisms. In the present study, we investigated the effects of rutin in amodel of HD, focusing on ASH neurons and antioxidant defense. We tested behavioral changes (touch response, movement, and octanol response), measured neuronal polyQ aggregates, and assessed degeneration using a dye-filling assay. In addition, we analyzed expression levels of heat-shock protein-16.2 and superoxide dismutase-3. Overall, our data demonstrate that chronic rutin treatment maintains the function of ASH neurons, and decreases the degeneration of their sensory terminations. We propose that rutin does so in a mechanism that involves antioxidant activity by controlling the expression of antioxidant enzymes and other chaperones regulating proteostasis. Our findings provide new evidence of rutin's potential neuroprotective role in themodel and should inform treatment strategies for neurodegenerative diseases and other diseases caused by age-related protein aggregation.

Study Type : Animal Study

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