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Abstract Title:

A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth.

Abstract Source:

Bioorg Med Chem Lett. 2015 Jul 15 ;25(14):2834-6. Epub 2015 May 6. PMID: 25981688

Abstract Author(s):

Ki Hyun Kim, Christine Beemelmanns, Jon Clardy, Shugeng Cao

Article Affiliation:

Ki Hyun Kim

Abstract:

A new octaketide, named cytosporone V (1), and two other known phenylethanoid glycosides (2-3), were isolated from the aerial parts of Pogostemon cablin (Blanco) Benth. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR and HR-MS. Compounds 1-3 displayed weak antibacterial activity against two gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus. All isolates were also evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds 2 and 3 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values ranging from 2.73 to 9.52μM.

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