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Abstract Title:

New Constituents from the Low Polar Fraction of the Fruits of Crataegus dahurica and Their Anti-Inflammatory Activity in RAW264.7 Cells.

Abstract Source:

Chem Biodivers. 2020 Feb ;17(2):e1900609. Epub 2020 Jan 29. PMID: 31916412

Abstract Author(s):

Bo-Bo Wang, Yang Gao, Li-Ya Chen, Chang-Long Zhang, Xiao-Qing Zhang, Hai-Long Zhang

Article Affiliation:

Bo-Bo Wang

Abstract:

The fruit of Crataegus dahurica Koehne was used to treat the disease of infantile indigestion and dyspepsia as an ethnic medicine and food. As a continuous work on finding the active constituents from the edible herbs, four new biphenyl derivatives (1-4), together with two known compounds (5 and 6), were obtained from the petroleum ether fraction of the fruits of C. dahurica. Their structures were determined by the extensive 1D and 2D NMR spectra and HR-MS spectrometry. Furthermore, the anti-inflammatory activities of all the isolated compounds were investigated, in which compound 4 showed moderately inhibitory effects on NO production in RAW264.7 cells without inducing cytotoxicity.

Study Type : In Vitro Study

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Sayer Ji
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