Abstract Title:

A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells.

Abstract Source:

Nat Prod Res. 2018 Feb 4:1-3. Epub 2018 Feb 4. PMID: 29397774

Abstract Author(s):

Li-Li Lou, Peng Zhao, Zhuo-Yang Cheng, Rui Guo, Guo-Dong Yao, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song

Article Affiliation:

Li-Li Lou


In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an ICvalue of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

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