A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells. - GreenMedInfo Summary
A new coumarin from Juglans mandshurica Maxim induce apoptosis in hepatocarcinoma cells.
Nat Prod Res. 2018 Feb 4:1-3. Epub 2018 Feb 4. PMID: 29397774
In this study, a new coumarin, juglansoside C (1) was isolated from the bark of Juglans mandshurica. Its chemical structure was identified by comprehensive spectroscopic analyses. The in vitro cytotoxicity assay showed that 1 exhibited moderate cytotoxicity against human hepatocellular carcinoma Hep3B cells with an ICvalue of 70.9 μM. Furthermore, Annexin V-FITC/PI staining assay indicated that 1 markedly induced apoptosis in Hep3B cells.