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Article Publish Status: FREE
Abstract Title:

New Promising Therapeutic Avenues of Curcumin in Brain Diseases.

Abstract Source:

Molecules. 2021 Dec 31 ;27(1). Epub 2021 Dec 31. PMID: 35011468

Abstract Author(s):

Tarek Benameur, Giulia Giacomucci, Maria Antonietta Panaro, Melania Ruggiero, Teresa Trotta, Vincenzo Monda, Ilaria Pizzolorusso, Dario Domenico Lofrumento, Chiara Porro, Giovanni Messina

Article Affiliation:

Tarek Benameur

Abstract:

Curcumin, the dietary polyphenol isolated from(turmeric), is commonly used as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also called "spice of life", in fact it is recognized that curcumin possesses important proprieties such as anti-oxidant, anti-inflammatory, anti-microbial, antiproliferative, anti-tumoral, and anti-aging. Neurodegenerative diseases such as Alzheimer's Diseases, Parkinson's Diseases, and Multiple Sclerosis are a group of diseases characterized by a progressive loss of brain structure and function due to neuronal death; at present there is no effective treatment to cure these diseases. The protective effect of curcumin against some neurodegenerative diseases has been proven by in vivo and in vitro studies. The current review highlights the latest findings on the neuroprotective effects of curcumin, its bioavailability, its mechanism of action and its possible application for the prevention or treatment of neurodegenerative disorders.

Study Type : Review

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