Melanoma and non-melanoma skin cancer chemoprevention: a role for nicotinamide?
Photodermatol Photoimmunol Photomed. 2017 Jul 5. Epub 2017 Jul 5. PMID: 28681504
Ultraviolet radiation (UVR) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8-oxo-7-hydrodeoxyguanosine. The production of reactive oxygen species by UVR also induces inflammatory cytokines that, together with the inherent immunosuppressive properties of UVR, propagate carcinogenesis. Nicotinamide (Vitamin B3 ) enhances DNA repair, modulates the inflammatory environment produced by UVR and reduces UV-induced immunosuppression. As nicotinamide reduces the incidence of actinic keratoses and non-melanoma skin cancers in high-risk individuals, and enhances repair of DNA damage in melanocytes, it is a promising agent for the chemoprevention of melanoma in high-risk populations. This article is protected by copyright. All rights reserved.