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Article Publish Status: FREE
Abstract Title:

Maternal Exposure to Non-nutritive Sweeteners Impacts Progeny's Metabolism and Microbiome.

Abstract Source:

Front Microbiol. 2019 ;10:1360. Epub 2019 Jun 20. PMID: 31281295

Abstract Author(s):

Stephanie Olivier-Van Stichelen, Kristina I Rother, John A Hanover

Article Affiliation:

Stephanie Olivier-Van Stichelen

Abstract:

Non-nutritive sweeteners (NNS) are marketed as sugar alternatives providing sweet taste with few or no calories. Yet their consumption has been linked to metabolic dysfunction and changes in the gut microbiome. NNS exposure mostly originates from diet beverages and sweetener packages in adults or breastmilk in infants. Consequences of early life exposure remain largely unknown. We exposed pregnant and lactating mice to NNS (sucralose, acesulfame-K) at doses relevant for human consumption. While the pups' exposure was low, metabolic changes were drastic, indicating extensive downregulation of hepatic detoxification mechanisms and changes in bacterial metabolites. Microbiome profiling confirmed a significant increase in firmicutes and a striking decrease of. Similar microbiome alterations in humans have been linked to metabolic disease and obesity. While our findings need to be reproduced in humans, they suggest that NNS consumption during pregnancy and lactation may have adverse effects on infant metabolism.

Study Type : Human Study

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Sayer Ji
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