Abstract Title:

Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death.

Abstract Source:

Biochem Biophys Res Commun. 2006 Sep 29;348(3):1101-6. Epub 2006 Aug 2. PMID: 16904642

Abstract Author(s):

Masakazu Kamata, Raymond P Wu, Dong Sung An, Jonathan P Saxe, Robert Damoiseaux, Michael E Phelps, Jing Huang, Irvin S Y Chen


Viral protein R (Vpr), one of the human immunodeficiency virus type 1 (HIV-1) accessory proteins, contributes to multiple cytopathic effects, G2 cell cycle arrest and apoptosis. The mechanisms of Vpr have been intensely studied because it is believed that they underlie HIV-1 pathogenesis. We here report a cell-based small molecule screen on Vpr induced cell death in the context of HIV-1 infection. From the screen of 504 bioactive compounds, we identified damnacanthal (Dam), a component of noni [corrected] as an inhibitor of Vpr induced cell death. Our studies illustrate a novel efficient platform for drug discovery and development in anti-HIV therapy which should also be applicable to other viruses.

Study Type : In Vitro Study

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