Abstract Title:

Morinda citrifolia Linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration.

Abstract Source:

J Med Food. 2011 Oct ;14(10):1159-66. Epub 2011 May 6. PMID: 21548805

Abstract Author(s):

Mairim Russo Serafini, Rodrigo Correia Santos, Adriana Gibara Guimarães, João Paulo Almeida Dos Santos, Alan Diego da Conceicão Santos, Izabel Almeida Alves, Daniel Pens Gelain, Paulo Cesar de Lima Nogueira, Lucindo José Quintans-Júnior, Leonardo Rigoldi Bonjardim, Adriano Antunes de Souza Araújo

Article Affiliation:

Department of Physiology, Federal University of Sergipe (UFS), São Cristóvão, Sergipe, Brazil.


Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as "Noni") has been used in folk medicine by Polynesians for over 2,000 years. It is reported to have a broad range of therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim of this study was to investigate the antioxidant, anti-inflammatory, antinociceptive, and antibacterial properties of the aqueous extract from M. citrifolia leaves (AEMC). Antioxidant activity was observed against lipid peroxidation, nitric oxide, and hydroxyl radicals. The antinociceptive effect of AEMC was observed in the acetic acid-induced writhing test at the higher dose. Moreover, AEMC significantly reduced the leukocyte migration in doses of 200 and 400 mg/kg and showed mild antibacterial activity. Together, the results suggest that properties of M. citrifolia leaf extract should be explored further in order to achieve newer tools for managing painful and inflammation conditions, including those related to oxidant states.

Study Type : In Vitro Study

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Sayer Ji
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